B.I.G.S.

BIGS


What is the B.I.G.S. and how can it help the Boerboel ?


B.I.G.S. (Boerboel International Genetic Screening) is a series of DNA tests to look for traits and disorders in the genetic make up of a dog. In this case the boerboel.

This can be an eye or kidney disorders etc etc.
170 health tests in total
32 tests concerning the Genotype of a dog. Does the dog carry the livernose gene or longhair gene, information about the coat colours. etc
Included in the package is also a DNA profile, done according the ISAG standard.

The DNA profile can, in the BI database, be used to determine the parenthood of a dog if a DNA profile is present of the father, mother and the pup.
Every dog, that has been B.I.G.S. tested, has now also two extra results. 1 is the GD (Gennetic Diversity) and the GHI (Genetic Health Index.

The GD short for Genetic Diversity. What does that mean ?
The GD determines the genetic diversity of the dog. The higher the number the better. Meaning more divers !!  We have 3 known values. 

1 x value of your own dog. The GD.
1 x the average (Median per 23-2-2017 is 38,90%) of ALL B.I.G.S. tested boerboels. (More then 300)
1 x the average (Median per 23-2-2017 is 34.60%) of ALL other breeds which are tested.

The GD of the boerboels is 12% higher compared to all other breeds. !

Example:
Your dog has a GD of 38,40%. This means that your dog has an average score.

For the tested boerboels the following is interesting:
Lowest GD score at this moment is (so less diversity): 26,10% (with an inbreeding of 20,10%) 
Highest GD score at this moment is (so more diversity): 43,50% (with an inbreeding of 5,6%) 

De GHI short for Genetic Health Index. What does that mean ?
The Genetic Health Index (GHI) describes the relative health level of the dog’s genome in relation to the other tested dogs in the database, considering both disease test results and measured genetic diversity. 

The dog’s GHI is not stable and is likely to change when the number of tested dogs increases. The average dog has a GHI value of 100 - the healthier the dog, the higher the index. For instance, severe inherited diseases, as well as low genetic diversity, would lower the index. 
The GHI value becomes breed-specific when a sufficient number of dogs have been tested within a breed !!! 

Please note that the GHI value ALONE should not be used for breeding selections. Mating of two dogs with a high GHI will not necessarily lead to healthier offspring as the dogs might be too closely related. 
Use the Mate Select Tool in the BI database to evaluate the genetic match and to see the estimated genetic health of the offspring.

The genetic health index does not take into account known inherited diseases within a breed for which there are no DNA tests or any test results obtained outside the database.

We will show you a good example, to the importance of this testing:

A lot of the boerboel breeders/owners know Piona Lugar, a well known studmale from the past. He is present in a lot of pedigrees.
Piona Lugar, among other old dogs, is also one of the old dogs used for the breed profile.
He had: 236 children, 1925 Grand children and 4696 Great Grand Children.

What a lot of people do not know is the fact that Piona Lugar was carrier of:
Canine Multifocal Retinopathy 1 (cmr1) disease (Eye Disorder)
Hyperuricosuria and Hyperuricemia (HUU) or Urolithiasis (kidney disorder)
Livernose gene.

This is exactly why BI always ask breeders to be ware of the Popular Sire Syndrome !!

So he passed on 3 different disorders/traits.
This means genetically:
Mating a carrier X non carrier = 50% of all children are carrier. 50% is free..
Mating carrier X carrier = 25% Affected /sufferer. 50% is carrier. 25% is free !!

Imagine how many dogs in your dogs pedigrees have/carry disorders that are undetected…….

This proves the importance of ANY (popular) Sire being completely tested before he starts mating !

The price of the B.I.G.S. and DNA tests are to be found on the mainpage under: "Fees and Costs."

BOERBOEL INTERNATIONAL.

Genetic testing is the only way forward !


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